2. Define the significance of the problem (how big is the problem, how serious, how many
people does it affect, what are the costs associated with the problem, what are the goals of
Healthy People 2020 related to the problem?).
3. What are measures aimed at early detection for the problem (who is at risk, what are the risk
factors both modifiable and non-modifiable? screening?)
4. What are the clinical manifestations (signs and symptoms?)
5. Discuss prevention measures related to the problem (lifestyle modifications related to diet,
exercise, smoking etc.
